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Article

A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia.

Anesthesiology - 1 Apr 2026

Riazi Sheila, Watt Stacey, Plester Jennifer, Biesecker Leslie G

Abstract excerpt

Malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle, is a potentially fatal reaction triggered by exposure to volatile anesthetics or succinylcholine. Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) has become the first line of testing for malignant hyperthermia susceptibility. However, genetic testing has sensitivity of only up to 70%. Contracture testing may be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41805301
DOI: 10.1097/ALN.0000000000005849
PMCID: PMC12965816

Genes

CACNA1S
RYR1
STAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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