Article

The molecular mechanism underlying KRAS regulation on STK31 expression in Pancreatic ductal adenocarcinoma

2023-11-07

Abstract excerpt

<title>Abstract</title> <p>KRAS mutations are common in pancreatic ductal adenocarcinoma (PDAC) but targeting mutant KRAS is still challenging. Kinase inhibitors are ideal targeted therapeutics for mutant KRAS-driven cancer. In our study, an esiRNA screening was performed to identify kinases that play a critical role in KRAS mutant driven PDAC. <italic>STK31</italic> was identified as a potential therapeutic targ...

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Literature Corpus work: 078c1de9-5dd9-5ed1-b89f-ac17a95068d7
DOI: 10.21203/rs.3.rs-3410770/v1

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