Article

An amyloidosis-associated polymorphism does not alter LECT2 stability <i>in vitro</i>

2022-03-01

Abstract excerpt

Amyloid fibrils formed from leukocyte chemotactic factor 2 (LECT2), a secreted human cytokine, are associated with kidney failure in the disease amyloid LECT2 (ALECT2) amyloidosis. This rare disease was recognized in 2008 and has a variable prevalence worldwide. The mechanisms which lead to ALECT2 fibril deposition are not known and there are no treatments other than kidney transplant. The LECT2 gene harbors a sin...

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Literature Corpus work: 0741a941-f0dd-5086-84f2-5ff9524ca5ae
DOI: 10.1101/2022.03.01.482540

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