Article

DNA extrusion size determines pathway choice during CAG repeat expansion

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> DNA triplet repeat expansion is the mutational cause of neurodegenerative disorders such as Huntington’s disease, myotonic dystrophy type 1, and fragile-X related disorders. There is a general consensus that recognition of extrahelical extrusions or hairpin-loop structures (formed by strand slippage) by the DNA mismatch repair protein MutSβ leads to repeat expansion by a mutagenic repair process...

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Literature Corpus work: 072d7242-11a6-50f3-83ef-cb8f0e4197bb
DOI: 10.1101/2025.05.12.653571

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