Article

Targeted Therapy with Vemurafenib in Brazilian Children with Refractory Langerhans Cell Histiocytosis: Two Case Reports and a Comprehensive Review

2024-03-08

Abstract excerpt

Langerhans cell histiocytosis (LCH) is characterized by inflammatory lesions featuring clonal infiltration. The BRAF mutation stands out as the most prevalent. Vemurafenib has emerged as a therapeutic option. The off-label use of VMF persists in Brazil. We will delineate the cases of two Brazilian children suffering from LCH with a positive response to VMF. Case Report I: The patient underwent standard therapy, bu...

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Literature Corpus work: 06f86822-a059-5fc1-bafd-bb7d02d00626
DOI: 10.22541/au.170994109.99444138/v1

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