Article
Refractory multisystem Langerhans cell histiocytosis in an infant: use of vemurafenib as a therapeutic option.
Archivos argentinos de pediatria - 31 Mar 2026
Tata M Victoria, Mantero M Natalia, Caristia Laura, Alfaro Tatiana, Morici Mercedes, Venialgo Gisela, Della Giovanna Patricia
Abstract excerpt
Langerhans cell histiocytosis (LCH) is a rare disease that predominantly affects children, characterized by the abnormal clonal proliferation of Langerhans cells with a broad clinical spectrum and prognosis. Refractory LCH to standard treatment usually presents multisystem and risk organs involvement, and mainly affects children under 2 years of age. In these cases, more than half present the BRAF-V600E mutation;...
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