Article

Integration of Insomnia-Related Network Perturbation Reveals Distinct Molecular Subtypes and Therapeutic Vulnerabilities in Breast Cancer

2025-12-09

Abstract excerpt

<title>Abstract</title> <p>Core circadian regulatory genes orchestrate vital physiological processes through temporal coordination of organ function, cellular metabolism, and mitotic regulation, critically influencing oncogenic transformation. Emerging evidence implicates circadian disruption as both prognostic determinant and therapeutic modulator in carcinogenesis. Leveraging genomic insights from 7,868 breast...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06aeb916-eb3f-5bc6-bb7d-1b3e8d772a54
DOI: 10.21203/rs.3.rs-8240898/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of Insomnia-Related Network Perturbation Reveals Distinct Molecular Subtypes and Therapeutic Vulnerabilities in Breast CancerDOI 10.21203/rs.3.rs-8240898/v1Read

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosisSemantic proximity Read

Elucidation of clinical implications Arising from circadian rhythm and insights into the tumor immune landscape in breast cancerSemantic proximity Read

Circadian pattern subtyping unveiling distinct immune landscapes in breast cancer patients for better immunotherapySemantic proximity Read

Insomnia score: predictive ability of insomnia, high-diagnostic and prognostic value for cancerSemantic proximity Read

Association between the Circadian Clock and the Tumor Microenvironment in Breast Cancer.Semantic proximity Read

Clock gene signature predicts Insomnia and links to sleep/circadian parametersSemantic proximity Read

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity.Semantic proximity Read

Dissecting Breast Cancer Heterogeneity Through Transcriptomics Insights of Diverse Etiological Factors for Common Biomarker DiscoverySemantic proximity Read

Identify and validate circadian regulators as potential prognostic markers and immune infiltrates in head and neck squamous cell carcinomaSemantic proximity Read

Inflammatory Proteins Mediate the Causal Association between Sleep Traits and Breast Cancer: A Mendelian Randomization Study.Semantic proximity Read

A signature based on circadian rhythm-associated genes for the evaluation of prognosis and the tumour microenvironment in HNSCCSemantic proximity Read

Remote reprogramming of hepatic circadian transcriptome by breast cancerSemantic proximity Read