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Article

Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells.

Disease models & mechanisms - 1 Apr 2016

Ito Naoto, Hendriks William T, Dhakal Jyotsna, Vaine Christine A, Liu Christina, Shin David, Shin Kyle, Wakabayashi-Ito Noriko, Dy Marisela, Multhaupt-Buell Trisha, Sharma Nutan, Breakefield Xandra O, Bragg D Cristopher

Abstract excerpt

X-linked dystonia-parkinsonism (XDP) is a hereditary neurodegenerative disorder involving a progressive loss of striatal medium spiny neurons. The mechanisms underlying neurodegeneration are not known, in part because there have been few cellular models available for studying the disease. The XDP haplotype consists of multiple sequence variations in a region of the X chromosome containingTAF1, a large gene with...

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Identifiers

PMID: 26769797
DOI: 10.1242/dmm.022590
PMCID: PMC4852502

Genes

TAF1

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