Article

A single-cell atlas of the peripheral immune response to severe COVID-19

2020-04-23

Abstract excerpt

<h4>ABSTRACT</h4> There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. Here, we apply single-cell RNA sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs) of 7 patients hospitalized with confirmed COVID-19 and 6 healthy controls. We identify substantial reconfiguration of peripheral immune cell phenotype i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0692255f-9d86-5c49-bbf5-969be1918dd5
DOI: 10.1101/2020.04.17.20069930

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single-cell atlas of the peripheral immune response to severe COVID-19DOI 10.1101/2020.04.17.20069930Read

Immune Response in Severe and Non-Severe Coronavirus Disease 2019 (COVID-19) Infection: A Mechanistic LandscapeSemantic proximity Read

Suppressive myeloid cells are a hallmark of severe COVID-19Semantic proximity Read

People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenSemantic proximity Read

Immune Cell Profiling of COVID-19 Patients in the Recovery Stage by Single-Cell SequencingSemantic proximity Read

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencingSemantic proximity Read

Cell specific peripheral immune responses predict survival in critical COVID-19 patientsSemantic proximity Read

Single-cell multi-omics analysis of the immune response in COVID-19Semantic proximity Read

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patientsSemantic proximity Read

The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centresSemantic proximity Read

Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza PatientsSemantic proximity Read

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19Semantic proximity Read

Delineating COVID-19 immunological features using single-cell RNA sequencingSemantic proximity Read