Article

MIRit: an integrative R framework for the identification of impaired miRNA-mRNA regulatory networks in complex diseases

2023-11-24

Abstract excerpt

<h4>Background</h4> MicroRNAs are crucial regulators of gene expression that participate in nearly every cellular process. Due to their central role, miRNAs are frequently implicated in the development of pathological conditions, as their dysregulation significantly disrupts normal cellular functioning. Consequently, a thorough characterization of the involvement of dysregulated miRNAs in disturbed pathways is im...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 066c8661-d612-555c-9924-13b664127ca5
DOI: 10.1101/2023.11.24.568528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MIRit: an integrative R framework for the identification of impaired miRNA-mRNA regulatory networks in complex diseasesDOI 10.1101/2023.11.24.568528Read

miRNA–mRNA Interaction Network Analysis in Alzheimer’s Disease for Biomarker DiscoverySemantic proximity Read

MicroRNA expression data analysis to identify key miRNAs associated with Alzheimer's diseaseSemantic proximity Read

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion.Semantic proximity Read

Literature-Identified Serum miRNA Signatures for Cognitive Decline: Integrated Analysis and Machine-Learning Diagnostics in Alzheimer’s DiseaseSemantic proximity Read

MicroRNA-Target Interaction Regulatory Network in Alzheimer’s DiseaseSemantic proximity Read

Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations.Semantic proximity Read

From biogenesis to deep modeling: a holistic review of miRNA-disease prediction computational methods with experimental comparison.Semantic proximity Read

Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathologySemantic proximity Read

MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases.Semantic proximity Read

Significant impact of miRNA-target gene networks on genetics of human complex traits.Semantic proximity Read

miRNA-miRNA crosstalk: from genomics to phenomics.Semantic proximity Read

Gene regulatory co-expression networks decipher potential lncRNA-miRNA-mRNA interactions modulating transcription regulation in neurodegenerationSemantic proximity Read