Article

Identification of Fibronectin 1 as a candidate genetic modifier in a <i>Col4a1</i> mutant mouse model of Gould syndrome

2020-11-07

Abstract excerpt

<h4>ABSTRACT</h4> Collagen type IV alpha 1 and alpha 2 (COL4A1 and COL4A2) are major components of almost all basement membranes. COL4A1 and COL4A2 mutations cause a multisystem disorder called Gould syndrome which can affect any organ but typically involves the cerebral vasculature, eyes, kidneys and skeletal muscles. The manifestations of Gould syndrome are highly variable and animal studies suggest that alle...

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Literature Corpus work: 06120158-0a2f-594d-8294-caa0203e0036
DOI: 10.1101/2020.11.06.371666

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