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Article

A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome.

The Journal of cell biology - 2 Jun 2025

Mao Mao, Ishikawa Yoshihiro, Labelle-Dumais Cassandre, Wang Xiaowei, Kuo Yien-Ming, Gaffney Uma B, Smith Megan E, Abdala Carlie N, Lebedev Matthew D, Paradee William J, Gould Douglas B

Abstract excerpt

Basement membranes (BMs) are specialized extracellular matrix (ECM) structures essential for organ morphogenesis, architecture, and function. BM composition and properties vary between tissues, developmental stages, and disease states, and there is only a rudimentary understanding of BM dynamics. Here, we introduce a versatile mouse model carrying a multifunctional dual-color fluorescence tagged allele with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40279671
DOI: 10.1083/jcb.202409153
PMCID: PMC12029515

Genes

COL4A1
COL4A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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