Article

scYeast: a Biological-knowledge-guided Foundation Model on Yeast Single-Cell Transcriptomics

2025-08-25

Abstract excerpt

Though large-scale pre-trained models are vital for foundational cell modeling, most focus on human or mouse systems, neglecting model organisms like yeast ( Saccharomyces cerevisiae ) and often failing to use existing biological prior knowledge effectively. To address this, we present scYeast, the first foundational cell model tailored for yeast that seamlessly embeds biological priors. scYeast employs a novel a...

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Identifiers and source

Literature Corpus work: 05f73c81-af26-5373-bfe1-7edc85766cb2
DOI: 10.1101/2025.08.20.671179

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