Article

Interleukin-36 promotes systemic Type-I IFN responses in severe psoriasis.

2018-12-14

Abstract excerpt

Psoriasis is an immune-mediated skin disorder associated with severe systemic co-morbidities. Both chronic and acute forms of the disease are characterised by abnormal interleukin (IL)-36 signalling. While the mechanisms whereby IL-36 promotes cutaneous inflammation are well established, its systemic effects have not been investigated. To address this issue, we initially measured leukocyte gene expression in gener...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0576f334-b380-56d2-b12c-9b3e54e5a726
DOI: 10.1101/496851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interleukin-36 promotes systemic Type-I IFN responses in severe psoriasis.DOI 10.1101/496851Read

The role of interleukin‐36 in health and disease statesSemantic proximity Read

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene SignatureSemantic proximity Read

Pathophysiology of generalized pustular psoriasis.Semantic proximity Read

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases.Semantic proximity Read

Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.Semantic proximity Read

Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RNSemantic proximity Read

Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.Semantic proximity Read

IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasisSemantic proximity Read

An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic targetSemantic proximity Read

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasisSemantic proximity Read

A viewpoint on the genetic determinants of generalised pustular psoriasis.Semantic proximity Read

Molecular aspects of Interleukin-36 cytokine activation and regulationSemantic proximity Read