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Microfluidic platform enables shear-less aerosolization of lipid nanoparticles for messenger RNA inhalation

2024-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Leveraging the extensive surface area of the lungs for gene therapy, inhalation route offers distinct advantages for delivery. Clinical nebulizers that employ vibrating mesh technology are the standard choice for converting liquid medicines into aerosols. However, they have limitations when it comes to delivering mRNA through inhalation, including severe damage to nanoparticles due to shearing f...

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Identifiers and source

Literature Corpus work
520db7d2-7102-51fa-8197-6b7b74dd0389
DOI
10.1101/2024.01.17.576136
Open publication

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Microfluidic platform enables shear-less aerosolization of lipid nanoparticles for messenger RNA inhalationDOI 10.1101/2024.01.17.576136
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