Article

Genome-wide analysis in 756,646 individuals provides first genetic evidence that <i>ACE2</i> expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

2020-12-16

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60, P =4.5x10 -13 ) that down-regulates ACE2 expression reduces risk of COVID-19 disease, providing human genetics support for the hypothesis that ACE2 levels influence COVID-19 risk. Further, we show that common genetic var...

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Literature Corpus work: 634a5b29-d910-56b7-a257-845425f032ac
DOI: 10.1101/2020.12.14.20248176

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