Article

Cas9-directed long-read sequencing to resolve optical genome mapping findings in leukemia diagnostics

2023-07-21

Abstract excerpt

Leukemias are genetically heterogeneous, and knowing the type of genetic aberration is clinically important for progression prognosis and choice of treatment. The standard-of-care (SOC) methods in leukemia diagnostics are karyotyping, SNP-array and FISH. Optical genome mapping (OGM) has emerged as their replacement as it can detect different types of structural aberrations simultaneously. However, although OGM can...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 05472944-3efa-5859-bb55-83342fe05f5e
DOI: 10.1101/2023.07.21.549991

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cas9-directed long-read sequencing to resolve optical genome mapping findings in leukemia diagnosticsDOI 10.1101/2023.07.21.549991Read

Cas9-directed long-read sequencing to resolve optical genome mapping findings in leukemia diagnosticsSemantic proximity Read

Next generation cytogenetics: comprehensive assessment of 48 leukemia genomes by genome imagingSemantic proximity Read

Genomic structural variants analysis in leukemia by a novel cytogenetic technique: Optical genome mappingSemantic proximity Read

Optical Genome Mapping for Cytogenetic Diagnostics in AMLSemantic proximity Read

Feasibility of Optical Genome Mapping in Cytogenetic Diagnostics of Hematological Neoplasms: A New Way to Look at DNASemantic proximity Read

Clinical Validation of Optical Genome Mapping for the Detection of Structural Variations in Hematological MalignanciesSemantic proximity Read

Application of Optical Genome Mapping for the Diagnosis and Risk Stratification of Myeloid and Lymphoid MalignanciesSemantic proximity Read

Optical genome mapping improves the accuracy of classification, risk stratification, and personalized treatment strategies for patients with acute myeloid leukemiaSemantic proximity Read

Optical Genome Mapping as an Alternative to FISH-Based Cytogenetic Assessment in Chronic Lymphocytic LeukemiaSemantic proximity Read

Analytic Validation of Optical Genome Mapping in Hematological MalignanciesSemantic proximity Read

Optical Genome Mapping: A New Tool for Cytogenomic AnalysisSemantic proximity Read

Application of Optical Genome Mapping to the Risk Stratification and Treatment Optimization of Hematologic DiseasesSemantic proximity Read