Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells.

Experimental cell research - 15 Feb 2010

Chen Charng-Jui, Nguyen Tung, Shively John E

Abstract excerpt

CEACAM1-4S (carcinoembryonic antigen-related cell adhesion molecule 1) is a type I membrane protein with a short (12-amino acid) cytoplasmic tail. Wild type CEACAM1-4S-transfected MCF7 cells form glands with lumena when grown in 3D culture, while null mutations of two putative phosphorylation sites (T457A and S459A) in the cytoplasmic domain fail to undergo lumen formation. When gene chip analysis was performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Calpain
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Transformed

Share to Cysteine Proteinase Inhibitors

Share to Dipeptides

Share to Epithelial Cells

Share to Protein Kinase C-delta

Source

Open in PubMed Open full text

Identifiers

PMID: 19909740
DOI: 10.1016/j.yexcr.2009.11.001
PMCID: PMC2868383

Genes

CEACAM1
CAPN9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Role of calpain-9 and PKC-delta in the apoptotic mechanism of lumen formation in CEACAM1 transfected breast epithelial cells.PMID 19909740Read ↗

CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture.Semantic proximity Read ↗

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formationSemantic proximity Read ↗

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formationSemantic proximity Read ↗

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.Semantic proximity Read ↗

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.Semantic proximity Read ↗

Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoformsSemantic proximity Read ↗

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.Semantic proximity Read ↗

Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.Semantic proximity Read ↗

Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.