Article

ATM Knockdown renders Glioma resistant to Temozolomide by Inhibiting IFIT1 Expression

2021-03-18

Abstract excerpt

<h4>Background: </h4> Temozolomide (TMZ) chemotherapy has been a standard of care in treating malignant glioma. Although TMZ chemotherapy can extend patient’s survival, resistance to TMZ is observed in most cases. The drug resistance is reported to be mainly mediated by O6- methyl guanine-DNA methyltransferase (MGMT) expression. <h4>Methods: </h4>: By means of molecular biology, cell biology, construction of nude...

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Literature Corpus work: 04732c95-ed14-5a63-b4dc-c053d4d4bcba
DOI: 10.21203/rs.3.rs-304467/v1

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