Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion.

Histochemistry and cell biology - 1 Aug 2012

Raffa Salvatore, Leone Laura, Scrofani Cristina, Monini Simonetta, Torrisi Maria Rosaria, Barbara Maurizio

Abstract excerpt

The keratinocyte growth factor (KGF/FGF7), produced by stromal cells, is a key paracrine mediator of epithelial proliferation, differentiation and migration. Expression of the growth factor is increased in wound healing and in hyperproliferative epithelial diseases, as a consequence of the activation of dermal fibroblasts by the inflammatory microenvironment. The middle ear cholesteatoma, an aural epidermal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Cells, Cultured

Share to Epithelial Cells

Share to Fibroblasts

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 22481617
DOI: 10.1007/s00418-012-0947-y
PMCID: PMC3407559

Genes

FGF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion.PMID 22481617Read ↗

Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanismSemantic proximity Read ↗

Pathway-Centric Transcriptomic Profiling of Middle Ear Cholesteatoma Identifies Selective Dysregulation of the IL-6/JAK-STAT/MAPK and MMP9/ZEB1 PathwaysSemantic proximity Read ↗

An FGF7-FGFR2-KLF4 feedback loop sustains anti-inflammatory signaling in epithelial cellsSemantic proximity Read ↗

MicroRNA let-7a suppresses the growth and invasion of cholesteatoma keratinocytesSemantic proximity Read ↗

Fibroblast growth factor-7 promotes repair of primary human bronchial epithelial cellsSemantic proximity Read ↗

Modeling the cholesteatoma microenvironment: coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix.Semantic proximity Read ↗

Characterization of primary cultures of cholesteatoma-associated fibroblasts.Semantic proximity Read ↗

The Roles of Growth Factors in Keratinocyte MigrationSemantic proximity Read ↗

Fibroblast growth factors in epithelial repair and cytoprotectionSemantic proximity Read ↗

Cholesteatoma Growth and ProliferationSemantic proximity Read ↗

Differential regulation of epithelial growth by gingival and periodontal fibroblasts in vitroSemantic proximity Read ↗

Alteration in cholesteatoma fibroblasts: induction of neoplastic-like phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.