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Progression along data-driven disease timelines is predictive of Alzheimer's disease in a population-based cohort.

NeuroImage - 1 Sept 2021

Venkatraghavan Vikram, Vinke Elisabeth J, Bron Esther E, Niessen Wiro J, Ikram M Arfan, Klein Stefan, Vernooij Meike W

Abstract excerpt

Data-driven disease progression models have provided important insight into the timeline of brain changes in AD phenotypes. However, their utility in predicting the progression of pre-symptomatic AD in a population-based setting has not yet been investigated. In this study, we investigated if the disease timelines constructed in a case-controlled setting, with subjects stratified according to APOE status, are...

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PMID: 34091030
DOI: 10.1016/j.neuroimage.2021.118233

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