Article

Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA

2022-11-01

Abstract excerpt

<title>Abstract</title> <p>The expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise their function and cause cytotoxicity. Focusing on cytoplasmic interaction of the CCCCGG ant...

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Literature Corpus work: 04093f69-ce15-52ec-b5f4-0ce0cbb615d2
DOI: 10.21203/rs.3.rs-2166624/v1

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