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Article

Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.

International journal of molecular sciences - 16 Jan 2026

Simancas-Racines Daniel, Jiménez-Flores Emilia, Montalvan Martha, Horowitz Raquel, Araujo Valeria, Reytor-González Claudia

Abstract excerpt

Endometriosis is traditionally conceptualized as a pelvic lesion-centered disease; however, mounting evidence indicates it is a chronic, systemic, and multifactorial inflammatory disorder. This review examines the molecular dialog between ectopic endometrial tissue, the immune system, and peripheral organs, highlighting mechanisms that underlie disease chronicity, symptom variability, and therapeutic resistance....

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Biomarkers
Endometriosis
Endometrium
Epigenesis, Genetic
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

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Identifiers

PMID: 41596555
DOI: 10.3390/ijms27020908
PMCID: PMC12842206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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