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Article

G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

2025-04-25

Abstract excerpt

G protein-coupled receptor 35 (GPR35) is an orphan receptor that is widely expressed in tissues including human osteoblasts and osteoclasts. Expression of the GPR35 gene and protein are downregulated in osteoporosis patients and in mouse models of the disease. Gpr35 -knockout mice have reduced bone mass, while GPR35 agonism rescues bone loss in rodent osteoporosis models indicating that GPR35 has an important rol...

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Identifiers and source

Literature Corpus work
03f2a280-113c-507f-840a-2aa57e6522e4
DOI
10.1101/2025.04.21.649743
Open publication

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G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cellsDOI 10.1101/2025.04.21.649743
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