Article

Association Between SARS-CoV-2 Mutations and Disease Severity Reveals Risk and Protective Effects Among Community-Sampled Patients in Israel

2026-01-29

Abstract excerpt

SARS-CoV-2 mutations play a key role in viral evolution, in immune escape, and potentially in disease severity. However, the clinical impact of most mutations remains poorly understood, particularly across different variants. A historical observational study was conducted using SARS-CoV-2 whole-genome sequencing data linked to clinical metadata from 175,503 COVID-19 cases in Israel. The dataset was stratified into...

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Literature Corpus work: 03f116aa-52cc-58d2-ae88-f9d83733665b
DOI: 10.64898/2026.01.26.26344903

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