Article

Identification of Dehydrogenase, Hydratase, and Aldolase Required for C17 Propionyl Residue Removal in Steroid Degradation by Comamonas testosteroni TA441: Structural and Functional Insights into the (ChsE1-ChsE2) 2 and (ChsH1-ChsH2 MaoC ) 2 -(Ltp2-ChsH2 DUF35 ) 2 Complexes

2025-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Bacterial steroid degradation is gaining attention for its diverse roles, such as Mycobacterium tuberculosis ’s reliance on the degradation of the C17 side chain of cholesterol for survival in host environments. ORF40 to ORF44 of Comamonas testosteroni TA441, previously characterized for its A-, B-, C-, and D-ring cleavage pathways, were hypothesized to correspond to the igr operon of M. tub...

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Literature Corpus work: 03c6e76b-2057-50ae-aa2a-bbe4e72b516b
DOI: 10.1101/2025.01.07.631791

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Identification of Dehydrogenase, Hydratase, and Aldolase Required for C17 Propionyl Residue Removal in Steroid Degradation by Comamonas testosteroni TA441: Structural and Functional Insights into the (ChsE1-ChsE2) 2 and (ChsH1-ChsH2 MaoC ) 2 -(Ltp2-ChsH2 DUF35 ) 2 ComplexesDOI 10.1101/2025.01.07.631791Read

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