Article

Genome-wide selection inference at short tandem repeats

2022-05-13

Abstract excerpt

Short tandem repeats (STRs) comprising repeated sequences of 1-6 bp are one of the largest sources of genetic variation in humans. STRs are known to contribute to a variety of disorders, including Mendelian diseases, complex traits, and cancer. Based on their functional importance, mutations at some STRs are likely to introduce negative effects on reproductive fitness over evolutionary time. We previously develope...

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Literature Corpus work: 036fc044-d935-53a8-b4f0-28972842a1bf
DOI: 10.1101/2022.05.12.491726

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