Back to search

Article

Pre-clinical in vitro and in vivo characterization of a maternal vaccination before conception to protect against severe neonatal infections caused by <i>Escherichia coli</i> K1

2022-12-29

Abstract excerpt

Preterm birth remains the leading cause of neonatal morbidity and mortality today. Genetic, immunological, and infectious substrates are suspected. Preterm infants are at higher risk of severe neonatal infections and the main cause of bacterial infection in this population is Escherichia coli K1. Unfortunately, women with history of preterm birth have a high risk of recurrence. Therefore, these women constitute a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
035c8bfb-2cb7-5daf-8d9d-84df31a34382
DOI
10.1101/2022.12.29.522168
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Pre-clinical in vitro and in vivo characterization of a maternal vaccination before conception to protect against severe neonatal infections caused by <i>Escherichia coli</i> K1DOI 10.1101/2022.12.29.522168
A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonatesSemantic proximity
Human systemic and mucosal immune responses support further exploration of a <i>Klebsiella pneumoniae</i> protein-based vaccineSemantic proximity
A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonatesSemantic proximity
Optimization of an Experimental Vaccine to Prevent <i>Escherichia coli</i> Urinary Tract InfectionSemantic proximity
High diversity of<i>Escherichia coli</i>causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approachSemantic proximity
Current concepts on K1 translocation of the blood–brain barrierSemantic proximity
Deciphering the roles of outer membrane protein A extracellular loops in the pathogenesis of Escherichia coli K1 meningitis.Semantic proximity
The interaction of N-glycans in Fcγ receptor I α-chain with Escherichia coli K1 outer membrane protein A for entry into macrophages: experimental and computational analysis.Semantic proximity
Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonatesSemantic proximity
Life-Threatening Infections Due to Live-Attenuated Vaccines: Early Manifestations of Inborn Errors of ImmunitySemantic proximity
The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic InfectionSemantic proximity
Protection conferred by intraperitoneal Group A <i>Streptococcus</i> immunization relies on macrophages and IFN-γ but not on concurrent adaptive immune responsesSemantic proximity
Select a neighboring publication to make it the new centre.