Article

A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates

2022-12-22

Abstract excerpt

<h4>Background</h4> Worldwide, Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but full understanding of the pathogenesis of this disease is not yet achieved. Moreover, to date, no vaccine is available against bacterial neonatal meningitis. <h4>Methods</h4> Here, we used Transposon Sequencing of saturated banks of mutants (TnSeq) to evaluate E. coli K1 genetic fitness in...

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Literature Corpus work: c1eccf99-76be-5a76-8bd1-55a813d37519
DOI: 10.1101/2022.12.22.521560

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