Article
Deciphering the roles of outer membrane protein A extracellular loops in the pathogenesis of Escherichia coli K1 meningitis.
The Journal of biological chemistry - 21 Jan 2011
Mittal Rahul, Krishnan Subramanian, Gonzalez-Gomez Ignacio, Prasadarao Nemani V
Abstract excerpt
Outer membrane protein A (OmpA) has been implicated as an important virulence factor in several gram-negative bacterial infections such as Escherichia coli K1, a leading cause of neonatal meningitis associated with significant mortality and morbidity. In this study, we generated E. coli K1 mutants that express OmpA in which three or four amino acids from various extracellular loops were changed to alanines, and...
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