Article

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

2022-04-30

Abstract excerpt

MEK inhibitors have yielded limited efficacy in KRAS-mutant lung adenocarcinoma (LUAD) patients due to drug resistance. We established trametinib-resistant KRAS-mutant LUAD cells and describe a state of “drug addiction” in a subset of resistant cases where cells are dependent on trametinib for survival. Dependence on ERK2 suppression underlies this phenomenon whereby trametinib removal hyperactivates ERK and resul...

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Literature Corpus work: 03436405-9082-5b9b-b3dc-99003acf299f
DOI: 10.1101/2022.04.29.490009

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