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Urinary Proteomic Signature of Mineralocorticoid Receptor Antagonism by Spironolactone: Evidence from the Randomized-Controlled HOMAGE and PRIORITY Trials

2023-04-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Mineralocorticoid receptor (MR) activation induces fibrosis. Urinary proteomic profiling (UPP) detects thousands of sequenced peptides, mainly derived from collagen. No previous study applied UPP to generate insights in the antifibrotic actions of MR antagonism. <h4>METHODS</h4> Based on urine sample availability, subsets of the open HOMAGE trial (n=290; 23.8% women; median ag...

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Literature Corpus work
02f5fa54-876e-544d-a131-c145d2b26b75
DOI
10.1101/2023.04.05.23288107
Open publication

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Urinary Proteomic Signature of Mineralocorticoid Receptor Antagonism by Spironolactone: Evidence from the Randomized-Controlled HOMAGE and PRIORITY TrialsDOI 10.1101/2023.04.05.23288107
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