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Article

Sickle Cell Disease in Brazil: Current Management.

Hemoglobin - 1 Jul 2024

da Silva Araújo Aderson, Silva Pinto Ana Cristina, de Castro Lobo Clarisse Lopes, Figueiredo Maria Stella, Menosi Gualandro Sandra Fátima, Olalla Saad Sara Teresinha, Cançado Rodolfo Delfini

Abstract excerpt

Sickle cell disease (SCD) comprises inherited red blood cell disorders due to a mutation in the β-globin gene (c20A > T, pGlu6Val) and is characterized by the presence of abnormal hemoglobin, hemoglobin S, hemolysis, and vaso-occlusion. This mutation, either in a homozygous configuration or in compound states with other β-globin mutations, leads to polymerization of hemoglobin S in deoxygenated conditions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38663998
DOI: 10.1080/03630269.2024.2344790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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