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[Preimplantation Genetic Diagnosis of α/β Complex Thalassemia by Next Generation Sequencing].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2021

He Tian-Wen, Lu Jian, Chen Chuang-Qi, Zhou Wei-Ning, Li Jing-Shu, Dong Yun-Qiao, DU Li, Yin Ai-Hua

Abstract excerpt

OBJECTIVE: To explore the application value of next generation sequencing (NGS) in preimplantation genetic diagnosis of α/β complex thalassemia couple. METHODS: The coding regions of α-globin genes (HBA1, HBA2) and β-globin gene (HBB) were selected as the target regions. The high-density and closely linked single nucleotide polymorphism (SNP) sites were selected as the genetic linkage markers in the upstream and...

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Identifiers

PMID: 34362516
DOI: 10.19746/j.cnki.issn.1009-2137.2021.04.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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