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Technically feasible solutions to challenges in preimplantation genetic testing for thalassemia: experiences of multiple centers between 2019 and 2022.

Journal of assisted reproduction and genetics - 1 Nov 2024

Ren Zi, Huang Peng, Wang Yong, Yao Yaxin, Ren Jun, Xu Linan, Shu Jinhui, Zhou Liang, Zhao Dunmei, Li Xiaolan, Zhang Zhiqiang, Zhang Chunhui, Sun Bolan, Lu Sijia, Qian Weiping, Zhou Hong, Fang Cong

Abstract excerpt

PURPOSE: In clinical practice, the success of preimplantation genetic testing for monogenic diseases (PGT-M) for thalassemia was hindered by the absence of probands, incomplete family members, or failure in detecting embryonic gene mutation sites. This study aimed to address these issues. METHODS: This retrospective study included 342 couples undergoing PGT-M for α- or β-thalassemia at three reproductive medicine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39256293
DOI: 10.1007/s10815-024-03240-4
PMCID: PMC11621276

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