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Article

Association of metabolomic aging acceleration and body mass index phenotypes with mortality and obesity-related morbidities.

Aging cell - 1 Apr 2025

Zeng Xiaomin, Chen Ruiye, Shi Danli, Zhang Xiayin, Su Ting, Wang Yaxin, Hu Yijun, He Mingguang, Yu Honghua, Shang Xianwen

Abstract excerpt

This study aims to investigate the association between metabolomic aging acceleration and body mass index (BMI) phenotypes with mortality and obesity-related morbidities (ORMs). 85,458 participants were included from the UK Biobank. Metabolomic age was determined using 168 metabolites. The Chronological Age-Adjusted Gap was used to define metabolomically younger (MY) or older (MO) status. BMI categories were...

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PMID: 39663904
DOI: 10.1111/acel.14435
PMCID: PMC11984667

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