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CAMKs support development of acute myeloid leukemia

26 Feb 2018

Abstract excerpt

BACKGROUND: We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also demonstrated that PirB is important for the development of acute myeloid leukemia (AML), but exactly how an inhibitory receptor such as PirB can support cancer development is intriguing. RESULTS:...

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PMID: 29482582
DOI: 10.1186/s13045-018-0574-8

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