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SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains

2024-08-26

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 variants of concern (VOC) have been associated with increased viral transmission and disease severity. We investigated the mechanisms of pathogenesis caused by variants using a host blood transcriptome profiling approach. We analysed transcriptional signatures of COVID-19 patients comparing those infected with wildtype (wt), alpha, delta or omicron strains seeking insights in...

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Literature Corpus work
02572038-08ae-594e-b5b1-886dac6b5f86
DOI
10.21203/rs.3.rs-4775119/v1
Open publication

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SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strainsDOI 10.21203/rs.3.rs-4775119/v1
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