Article

Coupled miR-155 Deficiency and Hypoxia Lead to the Upregulation of SLC2A3 (GLUT3) and VEGFA in the Leukemic B-cells

2023-04-29

Abstract excerpt

Hypoxia represents one of the key factors that stimulate the growth of leukemic cells in their niche. Leukemic cells in hypoxia are forced to reprogram their original transcriptome, miRNome, and metabolome. How the coupling of miRNAs/mRNAs helps to maintain or progress the leukemic status is still not fully described. MicroRNAs (miRNAs) regulate practically all biological processes within cells and play a crucial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01d1ea8f-dc28-5db6-8204-4c0438598560
DOI: 10.20944/preprints202304.1197.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coupled miR-155 Deficiency and Hypoxia Lead to the Upregulation of SLC2A3 (GLUT3) and VEGFA in the Leukemic B-cellsDOI 10.20944/preprints202304.1197.v1Read

[Expression and Prognostic Value of MiR-155 in Patients with Chronic Lymphocytic Leukemia].Semantic proximity Read

MiR-155/miR-150 network regulates progression through the disease phases of chronic lymphocytic leukemiaSemantic proximity Read

Hypoxic Regulation of Glucose Transport, Anaerobic Metabolism and Angiogenesis in Cancer: Novel Pathways and Targets for Anticancer TherapeuticsSemantic proximity Read

The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed stateSemantic proximity Read

MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor PrognosisSemantic proximity Read

Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5pSemantic proximity Read

Metabolic reprogramming of Kaposi's sarcoma associated herpes virus infected B-cells in hypoxia.Semantic proximity Read

Bioinformatic and metabolomic analysis reveals miR-155 regulates thiamine level in breast cancerSemantic proximity Read

miR155 Enhances Autophagy by Reducing MBD5 and METTL3 in Human Liver Cancer Stem CellsSemantic proximity Read

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.Semantic proximity Read

Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndromeSemantic proximity Read

Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCLSemantic proximity Read