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Article

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells.

Journal of immunology research - 1 Jan 2017

Garziera Marica, Scarabel Lucia, Toffoli Giuseppe

Abstract excerpt

The human leukocyte antigen-G (HLA-G) is considered an immune checkpoint molecule involved in tumor immune evasion. Hypoxia and the metabolic sensor hypoxia-inducible factor 1 (HIF-1) are hallmarks of metastasization, angiogenesis, and intense tumor metabolic activity. The purpose of this review was to examine original in vitro studies carried out in human cancer cell lines, which reported data about HLA-G...

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Share to Cell Hypoxia
Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-G Antigens

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Neoplasm Metastasis

Share to Neoplasms

Share to Neovascularization, Pathologic

Source

Open in PubMed Open full text

Identifiers

PMID: 28781970
DOI: 10.1155/2017/4587520
PMCID: PMC5525073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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