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Bioinformatic and metabolomic analysis reveals miR-155 regulates thiamine level in breast cancer

4 Dec 2014

Abstract excerpt

microRNA-155 (miR-155) is one of the well-known oncogenic miRNA implicated in various types of tumors. Thiamine, commonly known as vitamin B1, is one of critical cofactors for energy metabolic enzymes including pyruvate dehydrogenase, alpha ketoglutarate dehydrogenase, and transketolase. Here we report a novel role of miR-155 in cancer metabolism through the up-regulation of thiamine in breast cancer cells. A...

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PMID: 25484137
DOI: 10.1016/j.canlet.2014.11.058

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