Article

Generation of realistic virtual adult populations using a model-based copula approach

2024-02-23

Abstract excerpt

Incorporating realistic sets of patient-associated covariates, i.e., virtual populations, in pharmacometric simulation workflows is essential to obtain realistic model predictions. Current covariate simulation strategies often omit or simplify dependency structures between covariates. Copula models are multivariate distribution functions suitable to capture dependency structures between covariates with improved pe...

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Literature Corpus work: 1290aa4d-610c-506a-8e6d-eaff520a2df2
DOI: 10.1101/2024.02.22.24303086

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