Lung-Kidney Axis in Cystic Fibrosis: Early Urinary Markers of Kidney Injury Correlate with Neutrophil Activation and Worse Lung Function

Abstract excerpt

<h4>Background</h4> Adult people with cystic fibrosis (PwCF) have a higher risk of end-stage kidney disease than the general population. The nature and mechanism of kidney disease in CF are unknown. This study quantifies urinary kidney injury markers and examines the hypothesis that neutrophil activation and lung infection are associated with early kidney injury in CF. <h4>Methods</h4> Urinary total protein, album...

Topics

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• Anti-Infective Agents
• Body Weight
• Cystic Fibrosis
• Cystic Fibrosis Transmembrane Conductance Regulator
• Dose-Response Relationship, Drug
• Drug Dosage Calculations
• Mutation
• Renal Insufficiency, Chronic

Identifiers and source

Literature Corpus work

011c53b3-af6b-5c96-a8ce-a1f8096b31cb

DOI

10.1101/2023.11.10.23298378