Article

Tetramerisation governs SALL transcription factor function in development and disease

2025-10-27

Abstract excerpt

Spalt-like (SALL) proteins are C2H2 zinc-finger transcription factors important for embryogenesis, with mutations in SALL1 and SALL4 causing rare congenital disorders Townes-Brocks and Okihiro syndromes, respectively. While SALL proteins are known to associate with one another, the biological significance of the resulting complexes is unknown. Here we define a conserved glutamine-rich region that mediates SALL1/4...

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Literature Corpus work: 00ff184c-92ad-5b0b-b6f2-14a8d39cde51
DOI: 10.1101/2025.10.27.684836

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