Sex-specific microRNA regulators of Parkinson’s disease: insights from cohort-stratified simulations of compensatory pathway dynamics

Abstract excerpt

Parkinson’s disease (PD) exhibits sex differences in prevalence, symptom severity, and progression, suggesting distinct underlying molecular mechanisms. However, the pathophysiological mechanisms remain largely obscure, particularly in the context of the post-transcriptional regulations, where microRNAs (miRNAs) suppress the expression of multiple genes. Bulk transcriptomic data often blur these effects, especiall...

Topics

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• Autophagy in Disease and Therapy
• MicroRNA in disease regulation
• Neurological diseases and metabolism
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments
• RNA regulation and disease

Identifiers and source

Literature Corpus work

00e1a0d1-378d-57e2-a82e-be23d6793b46

DOI

10.1101/2025.09.29.679145