Article

Cardiac MRI measures as surrogate outcome for heart failure and atrial fibrillation: a Mendelian randomization analysis

2022-07-29

Abstract excerpt

<h4>Background</h4> drug development and disease prevention of heart failure (HF) and atrial fibrillation (AF) are impeded by a lack of robust early-stage surrogates. We determined to what extent cardiac magnetic resonance (CMR) measurements act as surrogates for the development of HF or AF in healthy individuals. <h4>Methods</h4> Genetic data was sourced on the association with 22 atrial and ventricular CMR measu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 008cd19f-b045-534e-a3be-bf918612aa29
DOI: 10.1101/2022.07.27.22278120

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cardiac MRI measures as surrogate outcome for heart failure and atrial fibrillation: a Mendelian randomization analysisDOI 10.1101/2022.07.27.22278120Read

Cardiac MRI to guide heart failure and atrial fibrillation drug discovery: a Mendelian randomization analysisSemantic proximity Read

Cardiac magnetic resonance markers of pre-clinical hypertrophic and dilated cardiomyopathy in genetic variant carriersSemantic proximity Read

Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study.Semantic proximity Read

MRI-Derived Fat Depots and Cardiometabolic Pathways Underlying Heart Failure Risk: A Mendelian Randomization StudySemantic proximity Read

Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers.Semantic proximity Read

Recommendation for Cardiac Magnetic Resonance Imaging-Based Phenotypic Study: Imaging PartSemantic proximity Read

The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart DiseaseSemantic proximity Read

Accelerated electrocardiographic aging of the heart as a risk determinant for atrial fibrillation: A Mendelian randomization studySemantic proximity Read

CMR-based cardiac phenotyping in different forms of heart failure.Semantic proximity Read

Leukocyte Telomere Length and Cardiac Structure and Function: A Mendelian Randomization StudySemantic proximity Read

INFLAMMATORY ACTIVATION, EPIGENETIC SIGNATURE AND MORPHO-STRUCTURAL ALTERATION IN A COHORT OF PATIENTS WITH CHRONIC HEART FAILURE AND PERMANENT ATRIAL FIBRILLATION: A CROSS-SECTIONAL STUDYSemantic proximity Read

Novel Insights into Causal Effects of Serum Lipids and Apolipoproteins on Cardiovascular Morpho-Functional Phenotypes.Semantic proximity Read