Article

GLS1 is a protective factor rather than a molecular target in ARID1A-mutated ovarian clear cell carcinoma

2021-09-04

Abstract excerpt

Targeting glutamine metabolism has emerged as a novel therapeutic strategy for several human cancers, including ovarian cancer. The primary target of this approach is the kidney isoform of glutaminase, glutaminase 1 (GLS1), a key enzyme in glutamine metabolism that is overexpressed in several human cancers. A first-in-class inhibitor of GLS1, called CB839 (Telaglenastat), has been investigated in several clinical...

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Literature Corpus work: 000a7325-65e9-5169-ad39-11086222da0e
DOI: 10.1101/2021.09.03.457161

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