Article
Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells.
The American journal of physiology - 1 Feb 1999
Nicke B, Tseng M J, Fenrich M, Logsdon C D
Abstract excerpt
CCK stimulates pleiotrophic responses in pancreatic acinar cells; however, the intracellular signaling pathways involved are not well understood. To evaluate the role of the ras gene product in CCK actions, a strategy involving in vitro adenoviral-mediated gene delivery of a dominant-negative mut...
Topics
- Adenoviridae
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Culture Techniques
- DNA
- Gene Expression Regulation
- Gene Transfer Techniques
- Genes, Dominant
- Male
- Mutation
- Pancreas
- Rats
- Rats, Wistar
- Sincalide
- ras Proteins