Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells.

The American journal of physiology - 1 Feb 1999

Nicke B, Tseng M J, Fenrich M, Logsdon C D

Abstract excerpt

CCK stimulates pleiotrophic responses in pancreatic acinar cells; however, the intracellular signaling pathways involved are not well understood. To evaluate the role of the ras gene product in CCK actions, a strategy involving in vitro adenoviral-mediated gene delivery of a dominant-negative mutant Ras (RasN17) was utilized. Isolated acini were infected with various titers of either a control adenovirus or an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Transfer Techniques

Share to Genes, Dominant

Share to Mutation

Share to Rats, Wistar

Source

Identifiers

PMID: 9950825
DOI: 10.1152/ajpgi.1999.276.2.G499

Genes

CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Adenovirus-mediated gene transfer of RasN17 inhibits specific CCK actions on pancreatic acinar cells.PMID 9950825Read ↗

Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells.Semantic proximity Read ↗

The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation.Semantic proximity Read ↗

The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity.Semantic proximity Read ↗

Suppression of malignant growth potentials of v-Src-transformed human gallbladder epithelial cells by adenovirus-mediated dominant negative H-Ras.Semantic proximity Read ↗

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.Semantic proximity Read ↗

Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.Semantic proximity Read ↗

The Significance of Ras Activity in Pancreatic Cancer InitiationSemantic proximity Read ↗

The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.