Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta.

doi:10.1007/s100380050096

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Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta.

Journal of human genetics - 1 Jan 1999

Miura K, Miyoshi O, Yun K, Inazawa J, Miyamoto T, Hayashi H, Masuzaki H, Yoshimura S, Niikawa N, Jinno Y, Ishimaru T

Abstract excerpt

Using a repetitive sequence of tandemly arrayed pentanucleotides in the human H19 3'-flanking region, we isolated a phage clone (lambda PEN11) which localized to chromosome 11p15.5. The lambda PEN11 phage encodes a 2.3-kb cDNA consisting of seven exons at least. The gene was mainly expressed in brain and pancreas (and less abundantly in testis), and demonstrated differential allele usage, with maternal expression...

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