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Article

Imprinted genes show unique patterns of sequence conservation.

BMC genomics - 22 Nov 2010

Hutter Barbara, Bieg Matthias, Helms Volkhard, Paulsen Martina

Abstract excerpt

BACKGROUND: Genomic imprinting is an evolutionary conserved mechanism of epigenetic gene regulation in placental mammals that results in silencing of one of the parental alleles. In order to decipher interactions between allele-specific DNA methylation of imprinted genes and evolutionary conservation, we performed a genome-wide comparative investigation of genomic sequences and highly conserved elements of...

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Identifiers

PMID: 21092170
DOI: 10.1186/1471-2164-11-649
PMCID: PMC3091771

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CTCF

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